4-氨基芳基胍和4-氨基苯甲脒衍生物作为强效和选择性尿激酶型纤溶酶原激活剂抑制剂
4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.
作者信息
Spencer Jeffrey R, McGee Danny, Allen Darin, Katz Bradley A, Luong Christine, Sendzik Martin, Squires Neil, Mackman Richard L
机构信息
Celera, 180 Kimball Way, South San Francisco, CA 94080, USA.
出版信息
Bioorg Med Chem Lett. 2002 Aug 5;12(15):2023-6. doi: 10.1016/s0960-894x(02)00312-8.
Abstract
The structure-based design of potent and selective urokinase-type plasminogen activator (uPA) inhibitors with 4-aminoarylamidine or 4-aminoarylguanidine S1 binding groups, is described.
摘要
本文描述了基于结构设计的强效且具选择性的尿激酶型纤溶酶原激活剂（uPA）抑制剂，其具有4-氨基芳基脒或4-氨基芳基胍S1结合基团。
Zotero 插件