2-(2-羟基-3-烷氧基苯基)-1H-苯并咪唑-5-脒衍生物作为强效且选择性的尿激酶型纤溶酶原激活剂抑制剂

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

作者信息

Mackman Richard L, Hui Hon C, Breitenbucher J Guy, Katz Bradley A, Luong Christine, Martelli Arnold, McGee Danny, Radika Kesavan, Sendzik Martin, Spencer Jeffrey R, Sprengeler Paul A, Tario James, Verner Erik, Wang Jing

机构信息

Celera, 180 Kimball Way, South San Francisco, CA 94080, USA.

出版信息

Bioorg Med Chem Lett. 2002 Aug 5;12(15):2019-22. doi: 10.1016/s0960-894x(02)00311-6.

DOI:10.1016/s0960-894x(02)00311-6

PMID:12113832

Abstract

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.

摘要

描述了基于先导分子2-(2-羟基-3-乙氧基苯基)-1H-苯并咪唑-5-甲脒(3a)开发强效和选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂的过程。