Gáspár Attila, Andrási Melinda, Kardos Szilvia
Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4010 Debrecen, POB. 21, Hungary.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Aug 5;775(2):239-46. doi: 10.1016/s1570-0232(02)00311-2.
The applicability of capillary zone electrophoresis (CZE) for the determination of cephalosporin antibiotics has been studied. In the case of the separation conditions optimised for fourteen cephalosporins, the precision of migration times was smaller than 1.3% RSD, and the values of the limit of detection ranged between 0.42 and 1.62 microg/ml. The proposed CZE method was applied to study the stability of cephalosporins in water at different temperatures (+25, +4 and -18 degrees C). It was established that the degradation of most cephalosporins was not higher than 20% at room temperature within 4 h of dissolution of these antibiotics.
研究了毛细管区带电泳（CZE）用于测定头孢菌素类抗生素的适用性。在针对14种头孢菌素优化的分离条件下，迁移时间的精密度小于1.3%相对标准偏差，检测限的值在0.42至1.62微克/毫升之间。所提出的CZE方法用于研究头孢菌素类抗生素在不同温度（+25、+4和 -18摄氏度）的水中的稳定性。结果表明，在室温下，这些抗生素溶解后4小时内，大多数头孢菌素的降解率不高于20%。
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