脂联素与皮马印第安人群2型糖尿病的发生

Adiponectin and development of type 2 diabetes in the Pima Indian population.

作者信息

Lindsay Robert S, Funahashi Tohru, Hanson Robert L, Matsuzawa Yuji, Tanaka Sachiyo, Tataranni P Antonio, Knowler William C, Krakoff Jonathan

机构信息

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA.

出版信息

Lancet. 2002 Jul 6;360(9326):57-8. doi: 10.1016/S0140-6736(02)09335-2.

DOI:10.1016/S0140-6736(02)09335-2

PMID:12114044

Abstract

Adiponectin is a collagen-like circulating protein secreted by adipocytes that is proposed to mediate obesity-related resistance to insulin. In a case-control series, we assessed the role of adiponectin in later development of type 2 diabetes in 70 patients who later developed type 2 diabetes and 70 controls, matched for body-mass index, age, and sex. Cases and controls were taken from the longitudinal study of health in the Pima Indian population. At baseline, the concentration of adiponectin was lower in cases than in controls (p=0.01) and individuals with high concentrations of this protein were less likely to develop type 2 diabetes than those with low concentrations (incidence rate ratio 0.63 [95% CI 0.43-0.92]; p=0.02).

摘要

脂联素是一种由脂肪细胞分泌的类似胶原蛋白的循环蛋白，被认为可介导与肥胖相关的胰岛素抵抗。在一项病例对照研究中，我们评估了70例后来患2型糖尿病的患者和70例体重指数、年龄和性别相匹配的对照者中脂联素在2型糖尿病后期发展中的作用。病例组和对照组来自皮马印第安人群健康纵向研究。基线时，病例组脂联素浓度低于对照组（p=0.01），且该蛋白浓度高的个体比浓度低的个体患2型糖尿病的可能性更小（发病率比0.63 [95%可信区间0.43 - 0.92]；p=0.02）。