Csáky T Z, Varga F
Am J Physiol. 1975 Sep;229(3):549-52. doi: 10.1152/ajplegacy.1975.229.3.549.
The outflux of barbital from the blood into the small intestine perfused with an isosmotic buffer of pH 9.5 in anesthetized rats was measured to determine the subepithelial capillary blood flow in the gut. It was shown that barbital clearance is blood flow limited when total blood flow to the small intestine varied between 0.3 and 1.3 ml/min per g wet gut. The barbital clearance amounted to an average of 50.3% of the total blood flow. The total mucosal blood flow determined by the use of the distribution of microspheres in the layers of gut wall was 62.76% of the total blood flow. It is concluded that, because of anatomical reasons, a subepithelial blood flow available for the transport process is somewhat less than the measured total mucosal blood flow.
在麻醉大鼠中，测量巴比妥从血液进入灌注pH 9.5等渗缓冲液的小肠的流出量，以确定肠道上皮下毛细血管血流量。结果表明，当小肠总血流量在每克湿肠0.3至1.3毫升/分钟之间变化时，巴比妥清除率受血流限制。巴比妥清除率平均占总血流量的50.3%。利用微球在肠壁各层中的分布确定的总黏膜血流量为总血流量的62.76%。得出的结论是，由于解剖学原因，可用于转运过程的上皮下血流量略低于测得的总黏膜血流量。
