一名患有AL淀粉样变性相关浆细胞发育异常患者的多发性内分泌肿瘤

Multiple Endocrine Neoplasms in a Patient with AL Amyloidosis-Associated Plasma Cell Dyscrasia.

作者信息

Seki Kunihiko, Wakatsuki Shingo, Hizawa Kazuo, Hasegawa Tadashi, Fujinaka Yuichi, Yokogoshi Hiroshi, Saito Shiro, Sano Toshiaki

出版信息

Endocr Pathol. 1997 Summer;8(2):153-160. doi: 10.1007/BF02739944.

DOI:10.1007/BF02739944

PMID:12114636

Abstract

Reports on patients with systemic amyloidosis-associated plasma cell dyscrasia (PCD) who have multiple endocrine tumors are very rare. Here we describe such a case. The patient was a 74-yr-old man with amyloid light-chain (AL) amyloidosis-associated PCD who had a null-cell adenoma of the pituitary and a latent papillary carcinoma of the thyroid gland. as well as a tubular adenoma of the sigmoid colon. The amyloid protein deposits reacted with the antibody to the n-immunoglobulin light chain. Since PCD by itself may be a risk factor for the development of subsequent neoplasms, the careful clinical evaluation of PCD patients is recommended.

摘要

关于患有系统性淀粉样变性相关浆细胞发育异常（PCD）且伴有多发性内分泌肿瘤的患者的报道非常罕见。在此我们描述这样一例病例。该患者为一名74岁男性，患有淀粉样轻链（AL）淀粉样变性相关PCD，伴有垂体无功能细胞瘤、甲状腺潜伏性乳头状癌以及乙状结肠管状腺瘤。淀粉样蛋白沉积物与抗n免疫球蛋白轻链抗体发生反应。由于PCD本身可能是后续肿瘤发生的一个危险因素，因此建议对PCD患者进行仔细的临床评估。