Husby G, Marhaug G, Sletten K
Cancer Res. 1982 Apr;42(4):1600-3.
Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. This was definitively proven by amino acid sequence analyses, which revealed structural homology between a purified subcomponent of the amyloid fibrils from both of the two cases of cancer-associated amyloidosis and previously sequenced amyloid A proteins. The chemical composition of the amyloid fibrils from systemic amyloidosis associated with cancer thus corresponded to that seen in amyloidosis reactive to inflammatory diseases and Hodgkin's disease. Amyloid proteins of immunoglobulin light chain type, which are found associated with myelomatosis, macroglobulinemia, and idiopathic (primary) amyloidosis, were not found in the two amyloid preparations. Renal cell carcinoma appears to be an effective stimulator of amyloid formation, while only one case of amyloidosis associated with mesothelioma has been reported previously.
对两例与癌症相关的系统性淀粉样变性病例的淀粉样纤维进行了研究，这两例病例分别以肾细胞癌和间皮瘤为潜在疾病。免疫化学研究强烈表明，在这两例与癌症相关的淀粉样变性病例中，淀粉样蛋白A均为主要的纤维成分。氨基酸序列分析最终证实了这一点，该分析揭示了这两例与癌症相关的淀粉样变性病例的淀粉样纤维纯化亚组分与先前测序的淀粉样蛋白A之间的结构同源性。因此，与癌症相关的系统性淀粉样变性的淀粉样纤维的化学成分与对炎症性疾病和霍奇金病有反应的淀粉样变性中所见的成分一致。在这两种淀粉样蛋白制剂中未发现与骨髓瘤病、巨球蛋白血症和特发性（原发性）淀粉样变性相关的免疫球蛋白轻链型淀粉样蛋白。肾细胞癌似乎是淀粉样蛋白形成的有效刺激物，而先前仅报道过一例与间皮瘤相关的淀粉样变性病例。
