d'Hollander L
Acta Psychiatr Belg. 1979 Sep-Oct;79(5):557-69.
Thirty five mentally retarded girls, with epilepsy associated with behavioral troubles, were treated with carbamazepine in a medicopedagogic institution for 4 months to 7 years. Fifty percent got better, thirty percent showed a disappearance of the epileptic spells and 67% showed an aggravation of the EEG. Improvement of behavior and absence of spells are more frequent in primary generalized epilepsy as in secondary generalized epilepsy and even less frequent in secondary generalized epilepsy. Results are better in epileptics only showing tonicoclonic crises than in those with absences. They are also better in dementia epileptica than in epilepsy without dementia. The aggravation of EEG, consistent with the disappearance of epileptic crises and behavioral improvement, is most often observed in patients with epileptic absences or progressive dementia.
35名患有与行为问题相关癫痫的智障女孩,在一家医学教育机构接受了4个月至7年的卡马西平治疗。50%的患者病情好转,30%的患者癫痫发作消失,67%的患者脑电图恶化。原发性全身性癫痫患者行为改善和无发作的情况比继发性全身性癫痫更常见,而继发性全身性癫痫则更少见。仅表现为强直阵挛发作的癫痫患者比有失神发作的患者效果更好。痴呆性癫痫患者的效果也比无痴呆的癫痫患者更好。脑电图恶化与癫痫发作消失和行为改善一致,最常出现在有癫痫失神发作或进行性痴呆的患者中。