Astal Z, El-Manama A, Sharif F A
Khan Younis Hospital Laboratory, Gaza-Palestinian Authority.
J Chemother. 2002 Jun;14(3):259-64. doi: 10.1179/joc.2002.14.3.259.
The aim of this study was to identify the microorganisms that cause "community-acquired" urinary tract infections among adults and to investigate their resistance to fourteen selected antimicrobial agents. The uropathogens identified in 121 positive midstream urine cultures from the 270 subjects included in this study were Escherichia coli (57.9%), Proteus species (9.9%), Enterobacter species (7.4%), Klebsiella species (6.6%), Pseudomonas species (5.8%), Staphylococcus saprophyticus (5.0%), Enterococcus species (3.3%), Acinetobacter species (2.5%), Citrobacter species (0.8%) and Staphylococcus aureus (0.8%). Isolates were subjected to antimicrobial susceptibility testing and a high proportion of the isolates was found to be resistant to amoxycillin (73.6%), doxycycline (68.6%) and trimethoprim-sulfamethoxazole (66.1%). The most effective drugs against all the isolates were ciprofloxacin (95.9%), amikacin (95.0%) and ceftazidime (94.2%). A high percentage of multiple-drug resistance was also observed for the majority of the isolates.
本研究的目的是确定导致成人“社区获得性”尿路感染的微生物,并调查它们对十四种选定抗菌药物的耐药性。在本研究纳入的270名受试者的121份阳性中段尿培养物中鉴定出的尿路病原体包括大肠杆菌(57.9%)、变形杆菌属(9.9%)、肠杆菌属(7.4%)、克雷伯菌属(6.6%)、假单胞菌属(5.8%)、腐生葡萄球菌(5.0%)、肠球菌属(3.3%)、不动杆菌属(2.5%)、柠檬酸杆菌属(0.8%)和金黄色葡萄球菌(0.8%)。对分离株进行了抗菌药敏试验,发现很大比例的分离株对阿莫西林(73.6%)、强力霉素(68.6%)和甲氧苄啶-磺胺甲恶唑(66.1%)耐药。对所有分离株最有效的药物是环丙沙星(95.9%)(此处原文有误,根据逻辑应为95.9%的分离株对环丙沙星敏感)、阿米卡星(95.0%)和头孢他啶(94.2%)。大多数分离株还观察到高比例的多重耐药性。 (注:原文中关于环丙沙星的“95.9%”表述可能有误,推测实际想表达的是对环丙沙星敏感的比例等类似意思,翻译时在括号内做了补充说明,以使逻辑更通顺)