从玉米中分离出的一种抗真菌胰蛋白酶抑制剂透过血脑屏障的运输。
Transport of an antifungal trypsin inhibitor isolated from corn across the blood-brain barrier.
作者信息
Banks William A, Niehoff Michael L, Brown Robert L, Chen Zhi-Yuan, Cleveland Thomas E
机构信息
Geriatric Research, Educational, and Clinical Center, Veterans Affairs Medical Center, 915 N Grand Boulevard, St. Louis, MO 63106, USA.
出版信息
Antimicrob Agents Chemother. 2002 Aug;46(8):2633-5. doi: 10.1128/AAC.46.8.2633-2635.2002.
Abstract
We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 microl/g. min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.
摘要
我们确定了从玉米中分离出的一种14千道尔顿的抗真菌蛋白胰蛋白酶抑制剂是否能够穿过血脑屏障。我们发现它通过一种可饱和机制以0.153微升/克·分钟的速率完全穿过了血脑屏障，每克脑摄取约0.082%的静脉注射剂量。
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