Ivarsson L, Rudenstam C M
Br J Cancer. 1975 Oct;32(4):502-8. doi: 10.1038/bjc.1975.252.
The present study of the effect of heparin and dextran 1000 on the metastasis formation after i.v. tumour cell injection in dextran non-sensitive rats using a syngeneic 20-methylcholanthrene induced fibrosarcoma showed that heparin treatment decreased with formation of pulmonary metastases in animals both untreated and treated with dextran 1000. Treatment with dextran 1000 increased the formation of pulmonary metastases in animals both untreated and treated with heparin and the effect of dextran 1000 was thus not affected by heparin treatment. Heparin did not have any direct action on the tumour cells, which influenced metastasis formation. The data suggest that heparin acts as an anticoagulant with decreased microthrombus formation around lodged cells and that dextrax 1000 stimulates metastasis formation primarily by mechanisms other than intravascular coagulation.
本研究利用同基因的20-甲基胆蒽诱导的纤维肉瘤，在葡聚糖不敏感大鼠静脉注射肿瘤细胞后，研究肝素和葡聚糖1000对转移形成的影响，结果显示，肝素治疗可降低未治疗及用葡聚糖1000治疗动物的肺转移形成。用葡聚糖1000治疗可增加未治疗及用肝素治疗动物的肺转移形成，因此葡聚糖1000的作用不受肝素治疗的影响。肝素对影响转移形成的肿瘤细胞没有任何直接作用。数据表明，肝素作为一种抗凝剂，可减少 lodged 细胞周围的微血栓形成，而葡聚糖1000主要通过血管内凝血以外的机制刺激转移形成。
