Chernyad'eva I F, Lopata N S, Afanasieva O I, Pokrovskii S N, Kukharchuk V V
Laboratory of Hemodialysis and Plasmapheresis, A. L. Myasnikov Institute of Cardiology, Russian Research-and-Production Center for Cardiology, Russian Ministry of Health, Moscow.
Bull Exp Biol Med. 2002 Apr;133(4):354-6. doi: 10.1023/a:1016289703241.
Plasma contents of apolipoprotein (a), apolipoprotein B 100, cholesterol, triglycerides, and vitamin E were measured in 2 patients with lipoprotein (a) concentration >100 mg/dl during the interaction with the anti-lipoprotein (a) immunosorbent. Intraindividual heterogeneity of apolipoprotein (a)-containing particles in the plasma was demonstrated. Polyclonal antibodies against lipoprotein (a) immobilized on Sepharose CL-4B more effectively removed free apolipoprotein (a) than complexes containing apolipoproteins B 100, apolipoprotein (a), lipids, and vitamin E.
在与抗脂蛋白（a）免疫吸附剂相互作用期间，对2名脂蛋白（a）浓度>100mg/dl的患者测定了血浆中载脂蛋白（a）、载脂蛋白B 100、胆固醇、甘油三酯和维生素E的含量。证实了血浆中含载脂蛋白（a）颗粒的个体内异质性。固定在琼脂糖CL-4B上的抗脂蛋白（a）多克隆抗体比含有载脂蛋白B 100、载脂蛋白（a）、脂质和维生素E的复合物更有效地去除游离载脂蛋白（a）。
