南印度男性受试者中组织型纤溶酶原激活剂、纤溶酶原激活剂抑制剂-1和纤维蛋白原与冠状动脉疾病的关系。

Relationship of tissue plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen with coronary artery disease in South Indian male subjects.

作者信息

Deepa R, Velmurugan K, Saravanan G, Dwarakanath V, Agarwal S, Mohan V

机构信息

Madras Diabetes Research Foundation, Gopalapuram.

出版信息

J Assoc Physicians India. 2002 Jul;50:901-6.

PMID:12126344

Abstract

AIM

Prevalence rates of coronary artery disease (CAD) are reported to be very high in Asian Indians. Conventional risk factors do not explain the high rates of CAD among Indians. Recently, several newer risk factors have been reported to be associated with CAD. We measured tissue plasminogen activator (tPA) antigen, plasminogen activator inhibitor-1 (PAI-1) and fibrinogen levels in South Indian diabetic and non-diabetic subjects with and without CAD.

METHODS

Four groups of subjects were studied (all males); Group 1 comprised of non-diabetic subjects without CAD (n=50). Non-diabetic subjects with CAD formed group 2 (n=50); group 3 comprised of type 2 diabetic patients without CAD (n=50) and group 4 consisted of type 2 diabetic patients with CAD (n=50). CAD was diagnosed based on coronary angiographic evidence of severe double or triple vessel disease.

RESULTS

Both diabetic and non-diabetic patients with CAD had significantly higher levels of tPA, PAI-1 and fibrinogen compared to non-diabetic without CAD (p < 0.05). Patients with CAD were distributed more in the upper tertiles of these risk factors compared to those without CAD. A strong association between tPA and PAI-1 was noted in the Pearson's correlation analysis (p < 0.001). Univariate regression analysis showed tPA (Odds ratio--1.12, p = 0.03), PAI-1 (Odds ratio--1.03, p = 0.008), fibrinogen (Odds ratio--1.01, p < 0.0001), serum cholesterol (Odds ratio--1.008, p = 0.04) and hypertension (Odds ratio--3.7, p = 0.0001) to be associated with CAD. Multiple logistic regression analysis revealed hypertension (Odds ratio--4.6, 95% confidence interval--2.113-9.950, p = 0.0001) and fibrinogen (Odds ratio--1.012, 95% confidence interval--1.007-1.018, p = 0.0001) as risk factors for CAD.

CONCLUSION

Our study suggests that prothrombogenic risk factors particularly fibrinogen may be associated with CAD in South Indians.

摘要

目的

据报道，亚洲印度人的冠状动脉疾病（CAD）患病率非常高。传统危险因素并不能解释印度人CAD的高发病率。最近，有报道称几种新的危险因素与CAD有关。我们测量了南印度患有和未患有CAD的糖尿病和非糖尿病受试者的组织纤溶酶原激活物（tPA）抗原、纤溶酶原激活物抑制剂-1（PAI-1）和纤维蛋白原水平。

方法

研究了四组受试者（均为男性）；第1组由无CAD的非糖尿病受试者组成（n = 50）。患有CAD的非糖尿病受试者组成第2组（n = 50）；第3组由无CAD的2型糖尿病患者组成（n = 50），第4组由患有CAD的2型糖尿病患者组成（n = 50）。根据严重双支或三支血管疾病的冠状动脉造影证据诊断CAD。

结果

与无CAD的非糖尿病患者相比，患有CAD的糖尿病和非糖尿病患者的tPA、PAI-1和纤维蛋白原水平均显著更高（p < 0.05）。与无CAD的患者相比，CAD患者在这些危险因素的上三分位数中的分布更多。在Pearson相关性分析中，tPA和PAI-1之间存在强关联（p < 0.001）。单因素回归分析显示tPA（比值比 - 1.12，p = 0.03）、PAI-1（比值比 - 1.03，p = 0.008）、纤维蛋白原（比值比 - 1.01，p < 0.