Zoghi Mehdi, Gürgün Cemil, Yavuzgil Oguz, Akilli Azem, Türkoglu Cüneyt, Kültürsay Hakan, Akin Mustafa
Ege University, Cardiology Department, Bornova, 35100, Izmir, Turkey.
Int J Cardiol. 2002 Aug;84(2-3):153-9. doi: 10.1016/s0167-5273(02)00140-7.
Left ventricular hypertrophy (LVH) increases the risk of ventricular arrhythmias and sudden death and has a significant effect on total cardiovascular mortality. QT dispersion (QTd) is a measure of inhomogeneous repolarization and is used as an indicator of arrhythmogenicity. In this study we detected QTd in patients with different etiologies of left ventricular hypertrophy and the effect of LVH in QTd on endurance athletes. The study group consisted of 147 white male subjects with 3 different etiologies of LVH and 30 healthy male individuals. The underlying etiologies of LVH were essential hypertension, valvular aortic stenosis and long-term training (athletic heart). QTd was measured by surface electrocardiogram and Bazett's formula was used to correct QTd for heart rate (QTcd). Left ventricular mass was determined by transthoracic echocardiography and left ventricular mass index was calculated in relation to body surface area. The QTcd was significantly higher in patients with pathological LVH (due to hypertension and aortic stenosis) than in the athletes' group (physiological LVH) and healthy subjects (P<0.05). The magnitude of QTcd was similar between athletes and the control group (P=0.6). The difference of QTcd between the groups with pathological LVH was not statistically significant (P=0.1). In conclusion; the increasing of QT dispersion is associated with only pathological conditions of LVH. The left ventricular hypertrophy has not a negative effect in QT dispersion on endurance athletes. The measurement of QT dispersion may be a non-invasive useful method for screening additional pathological conditions in endurance athletes.
左心室肥厚（LVH）会增加室性心律失常和猝死的风险，并对心血管疾病总死亡率产生重大影响。QT离散度（QTd）是复极不均一性的一种度量，用作致心律失常性的指标。在本研究中，我们检测了不同病因的左心室肥厚患者的QTd以及左心室肥厚对耐力运动员QTd的影响。研究组由147名患有3种不同左心室肥厚病因的白人男性受试者和30名健康男性个体组成。左心室肥厚的潜在病因包括原发性高血压、主动脉瓣狭窄和长期训练（运动员心脏）。通过体表心电图测量QTd，并使用Bazett公式校正心率后的QTd（QTcd）。通过经胸超声心动图测定左心室质量，并根据体表面积计算左心室质量指数。病理性左心室肥厚（由于高血压和主动脉狭窄）患者的QTcd显著高于运动员组（生理性左心室肥厚）和健康受试者（P<0.05）。运动员组和对照组之间的QTcd幅度相似（P=0.6）。病理性左心室肥厚组之间的QTcd差异无统计学意义（P=0.1）。总之，QT离散度的增加仅与左心室肥厚的病理状态相关。左心室肥厚对耐力运动员的QT离散度没有负面影响。测量QT离散度可能是一种用于筛查耐力运动员其他病理状况的无创有用方法。
