Zubairova D M, Storozhev A L
Fiziol Zh SSSR Im I M Sechenova. 1975 Sep;61(9):1428-32.
Alkaline phosphatase effect on platelets was studied. The dog platelet was found to have 1.3-10(7) phosphate groups available for hydrolytic action of alkaline phosphatase. Incubation of platelets during 1 hr in the medium containing alkaline phosphatase inhibits aggregation induced by ADP, adrenaline, collagen, thrombin, and Ca++. The mechanism of alkaline phosphatase action on platelet aggregation is discussed from two points of view: 1) interference in the energy supply and 2) the removal of ligands for calcium.
研究了碱性磷酸酶对血小板的作用。发现犬血小板有1.3×10⁷个磷酸基团可用于碱性磷酸酶的水解作用。血小板在含碱性磷酸酶的培养基中孵育1小时可抑制由二磷酸腺苷（ADP）、肾上腺素、胶原、凝血酶和钙离子诱导的聚集。从两个角度讨论了碱性磷酸酶对血小板聚集作用的机制：1）干扰能量供应；2）去除钙的配体。
