Fucs G B, Coutinho E M
Reproduccion. 1975 Apr-Jun;2(2):97-104.
Loss of libido associated with the use of oral contraceptives has been studied in 113 women of reproductive age who had taken a combined pill for periods ranging from 1 to 3 years. The patients were divided in four groups. In the first group (I) of 24 women oral contraceptive treatment was discontinued and all women received in intra-uterine contraceptive device (IUCD). The second group (II) of 36 patients, the brand of oral contraceptive was changed. Women in group (III) had their oral contraceptive maintained receiving in addition a mixture of an androgen and an estrogen (methyltestosterone 4 mg and ethynilestradiol 0.002 mg) daily. To women of group (IV) the oral contraceptive was discontinued but the androgen-estrogen mixture was given. All women in this group received an IUCD. Evaluation of the psyco-sexual parameters included changes in libido, time to reach an orgasm, duration and intensity or orgasms. Frequency of intercourse and response to autostimulation was also investigated. Libido was restored in 94.2% of patients in group II, in 97.3% of group III and in 92.8% of group IV. In group I only 55.6% of patients had libido fully restored. In view of the prompt restoration of libido in all groups except in patients discontinuing oral contraceptive therapy, it is suggested that loss of libido in oral contraceptive users has an important physological component which can be overcome probably by psychotherapy. Short term treatment with a mixture of methyltestosterone and ethynilestradiol seems to be highly effective in restoring libido in all patients.
对113名育龄妇女进行了研究,这些妇女服用复方口服避孕药1至3年,出现了性欲减退的情况。患者被分为四组。第一组(I)有24名妇女,停用口服避孕药,所有妇女都接受了宫内节育器(IUCD)。第二组(II)有36名患者,更换了口服避孕药的品牌。第三组的妇女继续服用口服避孕药,此外每天还接受雄激素和雌激素的混合物(甲基睾酮4毫克和炔雌醇0.002毫克)。第四组的妇女停用口服避孕药,但给予雄激素 - 雌激素混合物。该组所有妇女都接受了宫内节育器。对心理 - 性参数的评估包括性欲的变化、达到性高潮的时间、性高潮的持续时间和强度。还调查了性交频率和对自我刺激的反应。第二组94.2%的患者、第三组97.3%的患者和第四组92.8%的患者性欲恢复。在第一组中,只有55.6%的患者性欲完全恢复。鉴于除停用口服避孕药治疗的患者外,所有组的性欲都迅速恢复,表明口服避孕药使用者的性欲减退有重要的心理成分,可能通过心理治疗得以克服。甲基睾酮和炔雌醇的混合物短期治疗似乎对所有患者恢复性欲都非常有效。