库欣综合征伴大的垂体腺瘤，该腺瘤同时分泌促肾上腺皮质激素释放激素（CRH）和促肾上腺皮质激素（ACTH）。

Cushing's syndrome with a large pituitary adenoma producing both corticotropin-releasing hormone (CRH) and adrenocorticotropin (ACTH).

作者信息

Yamada Yuya, Ohashi Akiko, Inoue Toru, Sakaguchi Katsuhiko, Tsujimura Takahiro, Okamoto Daisuke, Itatani Hiroaki, Fujimoto Naomi, Kusaka Kazumasa, Fushimi Hisako

机构信息

Department of Internal Medicine, Tokushima Municipal Hospital.

出版信息

Intern Med. 2002 Jul;41(7):549-54. doi: 10.2169/internalmedicine.41.549.

DOI:10.2169/internalmedicine.41.549

PMID:12132523

Abstract

A 57-year-old man showed high serum cortisol, plasma adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) levels with a large pituitary tumor and a prostatic cancer. High dose dexamethasone did not suppress cortisol secretion and CRH administration did not stimulate cortisol secretion. After surgical removal of the pituitary tumor, plasma CRH, ACTH and serum cortisol levels were normalized. Histological examinations showed pituitary adenoma and prostatic adenocarcinoma, and pituitary adenoma was stained with both anti-CRH and anti-ACTH antibodies, but prostatic cancer was not stained. A CRH-producing pituitary adenoma is a new type of Cushing's syndrome.

摘要

一名57岁男性，患有大型垂体瘤和前列腺癌，血清皮质醇、血浆促肾上腺皮质激素（ACTH）和促肾上腺皮质激素释放激素（CRH）水平升高。高剂量地塞米松不能抑制皮质醇分泌，注射CRH也不能刺激皮质醇分泌。手术切除垂体瘤后，血浆CRH、ACTH和血清皮质醇水平恢复正常。组织学检查显示为垂体腺瘤和前列腺腺癌，垂体腺瘤用抗CRH和抗ACTH抗体染色均呈阳性，但前列腺癌未染色。产生CRH的垂体腺瘤是一种新型的库欣综合征。