Anticancer Hospital Theagenio, Thessaloniki, Greece.
Cell Mol Life Sci. 2010 Apr;67(8):1293-306. doi: 10.1007/s00018-010-0265-2. Epub 2010 Feb 9.
Malignant tumors express multiple factors that have some role in the regulating networks supporting their ectopic growth. Recently, increased interest has been developing in the expression and biological role of the neuropeptides and receptors of the corticotropin releasing factor (CRF) system, the principal neuroendocrine mediator of the stress response, especially in the light of several R&D programs for small molecule antagonists that could present some anticancer therapeutic benefit. In the present article, we review the literature suggesting that the CRF system could be involved in the regulation of human cancer development. Potential implication in growth, metastasis, angiogenesis, or immune parameters via activation of locally expressed receptors could be clinically exploited by presenting targets of new therapeutic approaches.
恶性肿瘤表达多种因子，这些因子在调节支持其异位生长的调控网络中具有一定作用。最近，人们对促肾上腺皮质激素释放因子 (CRF) 系统的神经肽及其受体的表达和生物学作用产生了浓厚的兴趣，CRF 系统是应激反应的主要神经内分泌介质，尤其是在考虑到一些小分子拮抗剂的研发计划时，这些拮抗剂可能具有一定的抗癌治疗益处。在本文中，我们回顾了文献，提示 CRF 系统可能参与了人类癌症发展的调控。通过激活局部表达的受体，该系统可能在生长、转移、血管生成或免疫参数方面具有临床应用潜力，为新的治疗方法提供了靶点。
