[Hyperacute graft versus host disease after allo-stem cell transplantation, analysis of 118 cases].

OBJECTIVE

To investigate the clinical manifestations, management, prognosis, and risk factors of hyperacute graft versus host disease (hGVHD) after allo-SCT cell transplantation all-SCT.

METHODS

The data of 118 patients aged 2 approximately 52 who underwent 120 times of allo-SCT were analyzed retrospectively.

RESULTS

hGVHD was observed in 17 patients with an incidence rate of 14.17%. The clinical manifestations included gastrointestinal symptoms (13/17), rash (13/17), fever (8/17), and hepatic dysfunction (6/17). Another 12 cases with only one organ injured were included in atypical hGVHD group. The two-year survival rates were 30.50%, 40.00%, and 61.67% in patients with typical hGVHD, patients with atypical hGVHD, and patients without hGVHD respectively. The condition of twenty-five cases with hGVHD improved after treatment with immunosuppressive drugs.

CONCLUSION

hGVHD is a common complication after allo-SCT that affects the prognosis dramatically. The risk factors of hGVHD include HLA mismatching, disease being in progressive stage just before allo-SCT, female in sex, and sex mismatching.