异基因造血干细胞移植后急性移植物抗宿主病及其危险因素的探讨
[Exploration of acute graft versus host disease and its risk factors after allo-hematopoietic stem cell transplantation].
作者信息
Chen Yu-hong, Huang Xiao-jun, Guo Nai-lan, Ren Han-yun, Zhang Yao-chen, Xu Lan-ping, Gao Zhi-yong, Lu Dao-pei
机构信息
Institute of Hematology and People's Hospital of Peking University, Beijing 100044, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2003 Feb;24(2):61-3.
OBJECTIVE
To explore the incidence, prognosis and risk factors of the acute graft versus host disease (aGVHD) after allo-hematopoietic stem cell transplantation (allo-HSCT).
METHODS
The clinical data of 118 cases undergone 120 times of allo-HSCT were analyzed.
RESULT
aGVHD was observed in 63 cases (52.57%) including 17 severe cases (14.17%). The patients with aGVHD had a poor outcome, the 2-year overall survival rates were 61.40%, 64.08% and 17.65% for the non aGVHD, mild (degree I-II) and severe (degree III-IV) aGVHD groups respectively (P < 0.01). However, the relapse rates were 12.48%, 20.53% and 0% with no statistic significance. Unrelated transplantation and HLA-mismatch were the risk factors for aGVHD.
CONCLUSION
aGVHD is a common complication after allo-HSCT, the earlier it takes place, the poorer the prognosis.
目的
探讨异基因造血干细胞移植（allo-HSCT）后急性移植物抗宿主病（aGVHD）的发生率、预后及危险因素。
方法
分析118例接受120次allo-HSCT的患者的临床资料。
结果
63例（52.57%）发生aGVHD，其中重度17例（14.17%）。aGVHD患者预后较差，非aGVHD组、轻度（Ⅰ-Ⅱ度）和重度（Ⅲ-Ⅳ度）aGVHD组的2年总生存率分别为61.40%、64.08%和17.65%（P<0.01）。然而，复发率分别为12.48%、20.53%和0%，差异无统计学意义。非血缘移植和HLA配型不合是aGVHD的危险因素。
结论
aGVHD是allo-HSCT后常见的并发症，发生越早，预后越差。
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