Lorincz Attila T, Castle Philip E, Sherman Mark E, Scott David R, Glass Andrew G, Wacholder Sholom, Rush Brenda B, Gravitt Patti E, Schussler John E, Schiffman Mark
Digene Corporation, Gaithersburg, MD 20708, USA.
Lancet. 2002 Jul 20;360(9328):228-9. doi: 10.1016/S0140-6736(02)09463-1.
Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, > or = 1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.
致癌性人乳头瘤病毒（HPV）被认为是宫颈癌发生所必需的。我们评估了在一个有20810名女性的队列中，此类病毒的较高病毒载量是否预示着未来发生宫颈上皮内瘤变3级（CIN3）或癌症（CIN3+）的风险，该队列通过细胞学筛查进行了10年的随访。我们使用杂交捕获2检测法对入组时采集的宫颈阴道灌洗液进行检测，测量了13种致癌性HPV的病毒载量（相对于1 pg/mL HPV 16阳性对照的相对光单位[RLU/PC]）。结果被分为四组（RLU/PC 1至<10、10至<100、100至<1000、≥1000）。虽然HPV的存在会显著增加CIN3+的风险，但高病毒载量并不能进一步预测CIN3+的风险。
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