Role of bacteriophage MAV1 as a mycoplasmal virulence factor for the development of arthritis in mice and rats.

作者信息

Tu Anh-Hue T, Lindsey J Russell, Schoeb Trenton R, Elgavish Ada, Yu Huilan, Dybvig Kevin

机构信息

Department of Genomics and Pathobiology, University of Alabama at Birmingham, 35294-0019, USA.

出版信息

J Infect Dis. 2002 Aug 1;186(3):432-5. doi: 10.1086/341458. Epub 2002 Jul 11.

The lysogenic bacteriophage MAV1 has been shown to be a virulence factor for the development of arthritis in rats infected with Mycoplasma arthritidis. In the present study, arthritis was evaluated by histopathologic examination to demonstrate that MAV1 is a virulence factor not only in the rat but also in the mouse. Specifically, the MAV1 lysogen 158L3-1 was more virulent than the nonlysogen strain 158 in DBA/2NCr, C3H/HeNCr, C3H/HeJ, and C3Smn.CB17-Prkdc(scid)/J mice, as well as in LEW rats.