Lledo Pierre-Marie, Carleton Alan, Vincent Jean-Didier
Institut Pasteur, Unité Postulante Perception et Mémoire olfactive, 25, rue du Docteur Roux, 75724 Paris, France.
J Soc Biol. 2002;196(1):59-65.
In this review, we discuss some of the neural processes involved in the perception of odors that, together with audition and vision, provide essential information for analyzing our surroundings. We shall see how odor detection and learning induce substantial structural and functional changes at the first relay of the olfactory system, i.e., the main olfactory bulb. Among the mechanisms that participate in these modifications is the persistence of a high level of interneuron neurogenesis within the adult olfactory bulb. Our goal is to present some observations related to the neurogenesis that may aid in understanding the neural mechanisms of sensory perception and shed light on the cellular basis of olfactory learning. We summarize the current ideas concerning the molecular mechanisms and organizational strategies used by the olfactory system to transduce, encode, and process information at various levels in the olfactory sensory pathway. Due to space constraints, this review focuses exclusively on the olfactory systems of vertebrates and primarily those of mammals.
在这篇综述中,我们讨论了一些与气味感知相关的神经过程,这些过程与听觉和视觉一起,为分析我们周围的环境提供了重要信息。我们将看到气味检测和学习如何在嗅觉系统的第一中继站,即主嗅球,引起实质性的结构和功能变化。参与这些变化的机制之一是成年嗅球内中间神经元高水平神经发生的持续存在。我们的目标是呈现一些与神经发生相关的观察结果,这些结果可能有助于理解感觉感知的神经机制,并阐明嗅觉学习的细胞基础。我们总结了目前关于嗅觉系统在嗅觉感觉通路的各个层面转导、编码和处理信息所使用的分子机制和组织策略的观点。由于篇幅限制,本综述仅专注于脊椎动物的嗅觉系统,主要是哺乳动物的嗅觉系统。