Palma-Carlos A G, Palma-Carlos M Laura, da Silva S Lopes
Hematology-Immunology Center (CHIUL), I Medical Clinics, Lisbon University-Faculty of Medicine and Clinical Allergy-Immunology Center (CAIC)-Lisbon, Portugal.
Allerg Immunol (Paris). 2002 Jun;34(6):208-12.
Mucocutaneous Candidiasis is discussed and his clinical aspects and immunologic mechanisms reviewed. On a series of 57 patients clinical presentation the antibodies patterns for IgE, IgG and IgM have been studied and the cellular response evaluated by flux cytometry decrease on Natural Killer cells NK, CD3-CD16+CD56+ was achieved in 55% of 51 patients and is the more relevant abnormality in cellular immunity. CD8 cytotoxic cells was also found in 8% of the patients. In some cases where Nk and CD8 cells were normal IgG antibodies were nul pointing to as relevant antibody dependent cellular cytotoxicity mechanisms in mucocutaneous Candidiasis.
本文讨论了黏膜皮肤念珠菌病，并对其临床方面和免疫机制进行了综述。在一组57例患者中，研究了IgE、IgG和IgM的抗体模式，并通过流式细胞术评估细胞反应，51例患者中有55%出现自然杀伤细胞（NK，CD3-CD16+CD56+）减少，这是细胞免疫中更相关的异常情况。8%的患者还发现了CD8细胞毒性细胞。在一些NK细胞和CD8细胞正常的病例中，IgG抗体为零，这表明抗体依赖性细胞毒性机制在黏膜皮肤念珠菌病中具有相关性。
