Ishiyama Midori, Iwabe Koji, Hida Mayumi, Okamura Takamitu, Yoshinaga Kentaro, Hidai Hiroko, Kobayashi Shoko, Sameshima Yuich, Mori Naoki, Teramura Masanao, Masuda Michihiko, Motoji Toshiko, Mizoguchi Hideaki
Department of Hematology, Tokyo Women's Medical University.
Rinsho Ketsueki. 2002 Jun;43(6):477-81.
We observed massive hemolysis after allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility (the donor was group O and the recipient group A). The patient was a 21-year-old man diagnosed as having Philadelphia chromosome-positive chronic myelogenous leukemia. On day 7 post-transplant, there was abrupt onset of massive hemolysis necessitating supportive treatment with transfusions. During the allogeneic peripheral blood stem cell transplantation the patient had received 2 x 10(8) CD3 positive cells/kg and 7.8 x 10(7) CD19 positive cells/kg donor lymphocytes with stem cells. The present case shows that in allogeneic peripheral blood stem cell transplantation with ABO incompatibility, severe hemolysis occurs early after transplantation presumably due to the transfusion of a large number of lymphocytes.
