Identification of a new HLA-B allele, B*3705 containing a Bw6 sequence motif.

HLA-B37, which is Bw4 type antigen frequently found in linkage disequilibrium with A1, Cw6 and DR10 in all ethnic groups, generally has a very low frequency all over the world. We report a new HLA-B37 allele, B3705, identified in two potential bone marrow donors in the Korean population. B3705, which has the Bw6 nucleotide segment, differs from B3701 in three nucleotide positions: 311, 317 and 319 in exon2. The serological profile of B3705 did not exhibit the B37 specificity. The putative haplotype associated with B3705 in the Korean population could be A02-Cw0602-DRB11001-DQA10101-DQB10501-DPB102011.