Yonezawa Masayori, Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University, Graduate School of Medicine.
Nihon Rinsho. 2002 Jul;60(7):1422-6.
Survival of patients with heart failure has improved over the past decade due to advances in medical therapy. However, sudden cardiac death continues to cause 35 to 65% of death. Ventricular arrhythmias are important causes of sudden cardiac death in patients with heart failure. The risks of antiarrhythmic drugs are increased in patients with heart failure. Therefore, in the absence of a clear indication, antiarrhythmic drug therapy should be avoided. A number of recent randomized trials have provided evidence that beta-adrenergic blockers, angiotensin-converting enzyme(ACE) inhibitors and angiotensin II receptor blockers(ARB) significantly reduces the risk of sudden death in patients with chronic congestive heart failure. For patients who have a history of sustained ventricular tachycardia(VT) or ventricular fibrillation(VF) amiodarone or an implantable cardioverter defibrillator(ICD) should be considered, and these therapy may benefit some high risk patients who have nonsustained VT.
在过去十年中,由于药物治疗的进展,心力衰竭患者的生存率有所提高。然而,心脏性猝死仍导致35%至65%的死亡。室性心律失常是心力衰竭患者心脏性猝死的重要原因。心力衰竭患者使用抗心律失常药物的风险会增加。因此,在没有明确指征的情况下,应避免使用抗心律失常药物治疗。最近的一些随机试验提供了证据,表明β-肾上腺素能阻滞剂、血管紧张素转换酶(ACE)抑制剂和血管紧张素II受体阻滞剂(ARB)可显著降低慢性充血性心力衰竭患者的猝死风险。对于有持续性室性心动过速(VT)或心室颤动(VF)病史的患者,应考虑使用胺碘酮或植入式心脏复律除颤器(ICD),这些治疗可能使一些有非持续性VT的高危患者受益。