Ng E Y K, Chua L T
School of Mechanical and Production Engineering, Nanyang Technological University, Singapore.
Proc Inst Mech Eng H. 2002;216(3):157-70. doi: 10.1243/0954411021536379.
Skin burn injury and heat tolerance in man is a complex interaction of physical heat exchange processes and the potential for physiological adjustments. In recently developed one-dimensional finite difference and two-dimensional finite element bioheat transfer based numerical models of the skin, the prediction of the thermal efficacy of cooling treatment was evaluated. With the use of a standard Arrhenius model for damage rate, the extent of burn injury was computed from the transient temperature solution. Simulated isotherms results for current models were found to be consistent in both one- (experimental) and two-dimensional (analytical) data. The two-dimensional code provided some additional precision to previously published models. This was due to the mesh-independent grid which enabled more accurate numerical prediction of thermal and injury patterns as they developed during the injury process. Numerical data obtained in the current study suggest that non-thermal factors must be considered in the calculation of the efficacy of postburn cooling therapy. However, when dealing with living tissue, any numerical model can provide only an approximation to conditions in real exposures. Together with analysis of variance, the models were used for investigating the precedence of the various parameters and the effects of varying these parameters on assessment of burn injury resulting from exposure of skin surface to heat sources (Part 2).
人体皮肤烧伤和耐热性是物理热交换过程与生理调节潜能之间复杂的相互作用。在最近基于一维有限差分和二维有限元生物热传递开发的皮肤数值模型中，对冷却治疗的热效能预测进行了评估。使用标准的阿累尼乌斯损伤率模型，根据瞬态温度解计算烧伤程度。发现当前模型的模拟等温线结果在一维（实验）和二维（分析）数据中都是一致的。二维代码为先前发表的模型提供了一些额外的精度。这是由于与网格无关的网格，使得在损伤过程中热和损伤模式发展时能够更准确地进行数值预测。当前研究中获得的数值数据表明，在计算烧伤后冷却疗法的效能时必须考虑非热因素。然而，在处理活体组织时，任何数值模型都只能提供对实际暴露条件的近似。连同方差分析一起，这些模型被用于研究各种参数的优先级以及改变这些参数对皮肤表面暴露于热源导致的烧伤损伤评估的影响（第2部分）。
