Kol Matthijs A, de Kruijff Ben, de Kroon Anton I P M
Department of Biochemistry of Membranes, Center for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Semin Cell Dev Biol. 2002 Jun;13(3):163-70. doi: 10.1016/s1084-9521(02)00044-7.
Phospholipids are synthesized in biogenic membranes, but only on one leaflet of the bilayer. To support balanced growth of the membrane, phospholipid translocation, or flip-flop, has to occur. Though consensus has been reached that flip-flop is most likely mediated by (a) membrane-associated protein(s), a dedicated flippase has not been identified yet in any biogenic membrane. The characteristics of the flip-flop process are summarized, and possible mechanisms, including the need for a dedicated flippase, are discussed.
磷脂在生物膜中合成，但仅在双层膜的一个小叶上。为了支持膜的平衡生长，磷脂转运或翻转必须发生。尽管已经达成共识，即翻转很可能由一种或多种膜相关蛋白介导，但在任何生物膜中尚未鉴定出专门的翻转酶。本文总结了翻转过程的特征，并讨论了可能的机制，包括对专门翻转酶的需求。
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