Suppr超能文献

在大鼠子宫模型中比较两种屏障、一种溶液和两种药物制剂对术后粘连的减轻作用。

Comparison of the reduction of postoperative adhesions by two barriers, one solution, and two pharmacologic agents in the rat uterine model.

作者信息

Yoldemir Tevfik, Sagol Sermet, Adakan Saban, Oztekin Kemal, Ozsener Serdar, Karadadas Nedim

机构信息

Second Obstetrics and Gynecology Clinic, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

出版信息

Fertil Steril. 2002 Aug;78(2):335-9. doi: 10.1016/s0015-0282(02)03224-7.

Abstract

OBJECTIVE

To evaluate the effects of two barriers, one solution, and two pharmacologic agents, in single or in combined use, for preventing postsurgical adhesion formation in the rat model.

DESIGN

A randomized, prospective study to evaluate the ability of leuprolide acetate, oxidized regenerated cellulose, medroxyprogesterone acetate, sodium hyaluronate, sodium hyaluronate/carboxymethyl cellulose, in single or in combined use, for preventing adhesion formation in a rat model.

ANIMAL(S): Wistar female rats.

SETTING

University animal laboratory.

INTERVENTION(S): Intramuscular injection of pharmacologic agents before surgery and intraperitoneal application of barriers and solution at the end of surgery.

MAIN OUTCOME MEASURE(S): Two weeks after surgery, a second laparotomy was performed and the extent of adhesion formation was determined.

RESULT(S): All the treatment groups had fewer, less severe adhesions when compared with controls. The combination of medroxyprogesterone acetate and oxidized regenerated cellulose did enhance the adhesion-reducing capacity of oxidized regenerated cellulose. The performance of sodium hyaluronate solution for adhesion prevention was statistically significant, when compared with oxidized regenerated cellulose alone, or sodium hyaluronate used with carboxymethyl cellulose film.

CONCLUSION(S): Pharmacologic agents, barriers, or solutions result in significant reduction of postsurgical adhesions. The sodium hyaluronate solution alone and medroxyprogesterone acetate treatment alone had the least adhesion prevention scores. However, neither monotherapy nor combined therapy proved to be significantly more beneficial.

摘要

目的

评估两种屏障、一种溶液和两种药物制剂单独或联合使用对大鼠模型术后粘连形成的预防效果。

设计

一项随机、前瞻性研究,以评估醋酸亮丙瑞林、氧化再生纤维素、醋酸甲羟孕酮、透明质酸钠、透明质酸钠/羧甲基纤维素单独或联合使用在大鼠模型中预防粘连形成的能力。

动物

雌性Wistar大鼠。

地点

大学动物实验室。

干预措施

术前肌肉注射药物制剂,手术结束时腹腔内应用屏障和溶液。

主要观察指标

术后两周进行第二次剖腹手术,确定粘连形成的程度。

结果

与对照组相比,所有治疗组的粘连数量更少、程度更轻。醋酸甲羟孕酮与氧化再生纤维素联合使用确实增强了氧化再生纤维素减少粘连的能力。与单独使用氧化再生纤维素或透明质酸钠与羧甲基纤维素膜联合使用相比,透明质酸钠溶液预防粘连的效果具有统计学意义。

结论

药物制剂、屏障或溶液可显著减少术后粘连。单独使用透明质酸钠溶液和单独使用醋酸甲羟孕酮治疗的粘连预防评分最低。然而,单一疗法或联合疗法均未证明具有明显更大的益处。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验