Lee Jung Hee, Jeong Bi O
Department of Orthopaedic Surgery, College of Medicine, Kyung Hee University, Seoul, Korea.
J Korean Neurosurg Soc. 2011 Nov;50(5):409-14. doi: 10.3340/jkns.2011.50.5.409. Epub 2011 Nov 30.
The aim of this study was to evaluate the impact of sodium hyaluronate-sodium carboxymethyl cellulose (HA-CMC), an anti-adhesive material for spinal surgery, on bone fusion by applying it to rat spinal models after lumbar posterolateral fusion.
Lumbar posterolateral fusion was performed at L4-5 using bone graft substitutes in 30 rats. HA-CMC was injected in 15 rats at a dose of 0.2 cc (HA-CMC group) and a saline solution of 0.2 cc in the other 15 rats (control group). Simple radiographs were taken until postoperative 9 weeks with an interval of one week. At postoperative 4 and 9 weeks, three dimensional computed tomography (3D CT) scanning was performed to observe the process of bone fusion. At 9 weeks, bone fusion was confirmed by gross examination and manual palpation.
There were no statistically significant differences in bone fusion between the two groups. 3D CT scanning did not reveal significant differences between the groups. The gross examination and manual palpation after autopsy performed at 9 weeks confirmed bone union in 93.3% of both groups.
The anti-adhesive material used for spinal surgery did not have adverse effects on spinal fusion in rats.
本研究旨在通过将透明质酸钠-羧甲基纤维素（HA-CMC）这种脊柱手术抗粘连材料应用于大鼠腰椎后外侧融合术后模型，评估其对骨融合的影响。
对30只大鼠进行L4-5节段腰椎后外侧融合，使用骨移植替代物。15只大鼠注射0.2 cc的HA-CMC（HA-CMC组），另外15只大鼠注射0.2 cc的盐溶液（对照组）。术后每周拍摄一次简单X线片，直至术后9周。术后4周和9周进行三维计算机断层扫描（3D CT）以观察骨融合过程。9周时，通过大体检查和手动触诊确认骨融合情况。
两组之间的骨融合情况无统计学显著差异。3D CT扫描未显示两组之间有显著差异。9周时尸检后的大体检查和手动触诊证实两组均有93.3%的骨愈合。
用于脊柱手术的抗粘连材料对大鼠脊柱融合无不良影响。
