Socin Hernán Valdés, Born Jacques, Wallemacq Caroline, Betea Daniela, Legros Jean Jacques, Beckers Albert
Department of Endocrinology, Centre Hospitalier Universitaire Sart Tilman, B35, Liège, Belgium.
Clin Neurol Neurosurg. 2002 Sep;104(4):367-70. doi: 10.1016/s0303-8467(02)00005-7.
Colloid cysts of the third ventricle are rare, benign cysts of endodermal origin. Between 1989 and 1999, eight patients with this lesion (five females, three males), with a mean age of 40.5 years (range 20-54), were identified out of 1354 operated for tumours of the central nervous system. Among the eight, two were familial. They were half sisters 38 and 28 years-old, who were diagnosed to have colloid cysts of the third ventricle on CT scanning. Transcortical excision yielded 10 and 15 mm sized colloid cysts, respectively. Moreover, both sisters developed a multinodular goiter associated with these congenital tumours. The second sibling developed hyperprolactinemia associated with macroprolactinemia. Pregnancy was only possible after bromocriptine treatment. These cases provide further evidences that colloid cysts probably have an autosomic recessive pattern of inheritance with variable penetrance.
第三脑室胶样囊肿是罕见的、起源于内胚层的良性囊肿。1989年至1999年间，在1354例接受中枢神经系统肿瘤手术的患者中，发现了8例患有这种病变的患者（5名女性，3名男性），平均年龄为40.5岁（范围20 - 54岁）。在这8例中，有2例是家族性的。她们是38岁和28岁的同父异母姐妹，经CT扫描诊断为第三脑室胶样囊肿。经皮质切除术分别切除了大小为10毫米和15毫米的胶样囊肿。此外，两姐妹均患有与这些先天性肿瘤相关的结节性甲状腺肿。第二个姐妹还出现了与巨泌乳素血症相关的高泌乳素血症。仅在溴隐亭治疗后才得以怀孕。这些病例进一步证明，胶样囊肿可能具有常染色体隐性遗传模式，且外显率可变。
