特质解离影响健康男性对胆囊收缩素四肽的行为反应。

Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man.

作者信息

Kellner Michael, Yassouridis Alexander, Hua Yun, Wendrich Mona, Naber Dieter, Wiedemann Klaus

机构信息

Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany.

出版信息

Psychiatry Res. 2002 Aug 5;111(1):93-6. doi: 10.1016/s0165-1781(02)00144-0.

DOI:10.1016/s0165-1781(02)00144-0

PMID:12140124

Abstract

Trait dissociation might influence the response to panicogens in normal controls. The behavioral effects of 25 microg of cholecystokinin tetrapeptide (CCK-4) were studied in 18 healthy men, nine each with high or low trait dissociation. Subjects with high trait dissociation showed a significantly lower increase of acute dissociative, anxiety and panic symptoms compared with subjects with low trait dissociation. Trait dissociation should be assessed in further behavioral challenge studies as a potentially important covariate.

摘要

特质解离可能会影响正常对照者对致惊恐剂的反应。在18名健康男性中研究了25微克四肽胆囊收缩素（CCK - 4）的行为效应，其中9名具有高特质解离或低特质解离。与低特质解离的受试者相比，高特质解离的受试者急性解离、焦虑和惊恐症状的增加显著更低。在进一步的行为挑战研究中，特质解离应作为一个潜在的重要协变量进行评估。