Aluoja A, Shlik J, Vasar V, Kingisepp P H, Jagomägi K, Vasar E, Bradwejn J
Department of Psychiatry, University of Tartu, Estonia.
Psychiatry Res. 1997 Jan 15;66(1):59-67. doi: 10.1016/s0165-1781(96)02948-4.
This article examines the effect of baseline anxiety, anxiety sensitivity and dysfunctional attitudes on the response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers. CCK-4 and placebo were administered to 14 subjects in a double-blind manner. Four volunteers experienced a panic attack after CCK-4 administration. Those subjects who panicked had significantly higher baseline scores on dysfunctional attitudes. Dysfunctional thought patterns appeared also to predict number of symptoms and experience of cognitive and affective symptoms during injection. Baseline anxiety as well as anxiety sensitivity predicted reactions to placebo but not panic responses to CCK-4. Results suggest that a general tendency towards erroneous interpretation of information has some role in mediating the panicogenic effects of CCK-4, and also interpersonal sensitivity may constitute a vulnerability factor for panic. Psychological factors that have been considered more specific to panic disorder, namely high state and trait anxiety as well as anxiety sensitivity, appeared mainly to determine general reactions to a threatening situation.
本文研究了基线焦虑、焦虑敏感性和功能失调性态度对健康志愿者胆囊收缩素四肽（CCK - 4）反应的影响。以双盲方式向14名受试者注射CCK - 4和安慰剂。4名志愿者在注射CCK - 4后经历了惊恐发作。那些出现惊恐发作的受试者在功能失调性态度方面的基线得分显著更高。功能失调性思维模式似乎也能预测注射期间的症状数量以及认知和情感症状的体验。基线焦虑以及焦虑敏感性可预测对安慰剂的反应，但不能预测对CCK - 4的惊恐反应。结果表明，对信息进行错误解读的一般倾向在介导CCK - 4的致惊恐效应中起一定作用，而且人际敏感性可能构成惊恐的一个易患因素。那些被认为更具惊恐障碍特异性的心理因素，即高状态焦虑和特质焦虑以及焦虑敏感性，似乎主要决定了对威胁情境的一般反应。
