药物发现的筛选：首要问题。 - Suppr

Suppr

超能文献

Screening for drug discovery: the leading question.

作者信息

Smith Adam

出版信息

Nature. 2002 Jul 25;418(6896):453-9. doi: 10.1038/418453a.

DOI:10.1038/418453a

PMID:12140563

Abstract

摘要

相似文献

Screening for drug discovery: the leading question.

Nature. 2002 Jul 25;418(6896):453-9. doi: 10.1038/418453a.

Drug discovery: the leading edge.

Nature. 2004 Jul 1;430(6995):109-15. doi: 10.1038/430109a.

High throughput screening: early successes indicate a promising future.

J Biomol Screen. 2001 Jun;6(3):137-40. doi: 10.1177/108705710100600303.

China's unique position in discovery and preclinical research.

Drug Discov Today. 2007 Jan;12(1-2):4-7. doi: 10.1016/j.drudis.2006.11.009. Epub 2006 Nov 28.

Lab automation and robotics: Automation on the move.

Nature. 2003 Feb 6;421(6923):661, 663, 665-6. doi: 10.1038/421661a.

Chemistry plans a structural overhaul.

Nature. 2002 Sep 12;419(6903):4-7. doi: 10.1038/nj6903-04a.

Drug target validation: Hitting the target.

Nature. 2003 Mar 20;422(6929):341, 343, 345 passim. doi: 10.1038/422341a.

Screening for content--the evolution of high throughput.

Nat Biotechnol. 2003 Aug;21(8):859-64. doi: 10.1038/nbt0803-859.

Building biomanufacturing capacity--the chapter and verse.

Nat Biotechnol. 2006 May;24(5):503-5. doi: 10.1038/nbt0506-503.

Connecting genes, drugs and diseases.

Nat Biotechnol. 2006 Nov;24(11):1365-6. doi: 10.1038/nbt1106-1365.

引用本文的文献

Role of artificial intelligence in revolutionizing drug discovery.

Fundam Res. 2024 May 9;5(3):1273-1287. doi: 10.1016/j.fmre.2024.04.021. eCollection 2025 May.

Accelerating antimicrobial peptide design: Leveraging deep learning for rapid discovery.

PLoS One. 2024 Dec 20;19(12):e0315477. doi: 10.1371/journal.pone.0315477. eCollection 2024.

A molecular video-derived foundation model for scientific drug discovery.

Nat Commun. 2024 Nov 8;15(1):9696. doi: 10.1038/s41467-024-53742-z.

Research in the Field of Drug Design and Development.

Pharmaceuticals (Basel). 2023 Sep 11;16(9):1283. doi: 10.3390/ph16091283.

Droplet-Based Microfluidics: Applications in Pharmaceuticals.

Pharmaceuticals (Basel). 2023 Jun 28;16(7):937. doi: 10.3390/ph16070937.

Emerging trends in organ-on-a-chip systems for drug screening.

Acta Pharm Sin B. 2023 Jun;13(6):2483-2509. doi: 10.1016/j.apsb.2023.02.006. Epub 2023 Feb 15.

Network Analysis of Molecular Dynamics Sectors in the p53 Protein.

ACS Omega. 2022 Dec 20;8(1):571-587. doi: 10.1021/acsomega.2c05635. eCollection 2023 Jan 10.

Drug Design-Past, Present, Future.

Molecules. 2022 Feb 23;27(5):1496. doi: 10.3390/molecules27051496.

A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability.

Bull Math Biol. 2022 Feb 7;84(3):39. doi: 10.1007/s11538-021-00982-5.

Analysis of the effects of related fingerprints on molecular similarity using an eigenvalue entropy approach.

J Cheminform. 2021 Mar 23;13(1):27. doi: 10.1186/s13321-021-00506-2.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

Screening for drug discovery: the leading question.

Nature. 2002 Jul 25;418(6896):453-9. doi: 10.1038/418453a.

Drug discovery: the leading edge.

Nature. 2004 Jul 1;430(6995):109-15. doi: 10.1038/430109a.

High throughput screening: early successes indicate a promising future.

J Biomol Screen. 2001 Jun;6(3):137-40. doi: 10.1177/108705710100600303.

China's unique position in discovery and preclinical research.

Drug Discov Today. 2007 Jan;12(1-2):4-7. doi: 10.1016/j.drudis.2006.11.009. Epub 2006 Nov 28.

Lab automation and robotics: Automation on the move.

Nature. 2003 Feb 6;421(6923):661, 663, 665-6. doi: 10.1038/421661a.

Chemistry plans a structural overhaul.

Nature. 2002 Sep 12;419(6903):4-7. doi: 10.1038/nj6903-04a.

Drug target validation: Hitting the target.

Nature. 2003 Mar 20;422(6929):341, 343, 345 passim. doi: 10.1038/422341a.

Screening for content--the evolution of high throughput.

Nat Biotechnol. 2003 Aug;21(8):859-64. doi: 10.1038/nbt0803-859.

Building biomanufacturing capacity--the chapter and verse.

Nat Biotechnol. 2006 May;24(5):503-5. doi: 10.1038/nbt0506-503.

Connecting genes, drugs and diseases.

Nat Biotechnol. 2006 Nov;24(11):1365-6. doi: 10.1038/nbt1106-1365.

引用本文的文献

Role of artificial intelligence in revolutionizing drug discovery.

Fundam Res. 2024 May 9;5(3):1273-1287. doi: 10.1016/j.fmre.2024.04.021. eCollection 2025 May.

Accelerating antimicrobial peptide design: Leveraging deep learning for rapid discovery.

PLoS One. 2024 Dec 20;19(12):e0315477. doi: 10.1371/journal.pone.0315477. eCollection 2024.

A molecular video-derived foundation model for scientific drug discovery.

Nat Commun. 2024 Nov 8;15(1):9696. doi: 10.1038/s41467-024-53742-z.

Research in the Field of Drug Design and Development.

Pharmaceuticals (Basel). 2023 Sep 11;16(9):1283. doi: 10.3390/ph16091283.

Droplet-Based Microfluidics: Applications in Pharmaceuticals.

Pharmaceuticals (Basel). 2023 Jun 28;16(7):937. doi: 10.3390/ph16070937.

Emerging trends in organ-on-a-chip systems for drug screening.

Acta Pharm Sin B. 2023 Jun;13(6):2483-2509. doi: 10.1016/j.apsb.2023.02.006. Epub 2023 Feb 15.

Network Analysis of Molecular Dynamics Sectors in the p53 Protein.

ACS Omega. 2022 Dec 20;8(1):571-587. doi: 10.1021/acsomega.2c05635. eCollection 2023 Jan 10.

Drug Design-Past, Present, Future.

Molecules. 2022 Feb 23;27(5):1496. doi: 10.3390/molecules27051496.

A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability.

Bull Math Biol. 2022 Feb 7;84(3):39. doi: 10.1007/s11538-021-00982-5.

Analysis of the effects of related fingerprints on molecular similarity using an eigenvalue entropy approach.

J Cheminform. 2021 Mar 23;13(1):27. doi: 10.1186/s13321-021-00506-2.