Trinh Thi Ngoc Diep, Do Hoang Dang Khoa, Nam Nguyen Nhat, Dan Thach Thi, Trinh Kieu The Loan, Lee Nae Yoon
Department of Materials Science, School of Applied Chemistry, Tra Vinh University, Tra Vinh City 87000, Vietnam.
NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ward 13, District 04, Ho Chi Minh City 70000, Vietnam.
Pharmaceuticals (Basel). 2023 Jun 28;16(7):937. doi: 10.3390/ph16070937.
Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.
基于微滴的微流控技术为诊断、食品科学和药物发现等各个领域的应用提供了巨大机遇。微滴为在微尺度体积样本中进行单个反应提供了一个隔离的环境，从而实现快速反应，具有高灵敏度、高通量和低交叉污染风险。由于具有若干显著特性，基于微滴的微流控技术得到了深入研究。在本综述中，我们讨论微滴微流控技术的影响，尤其关注药物筛选和研发。此外，我们调查了各种器件制造以及微滴生成/操控方法。我们还重点介绍了过去5年内有关药物合成和递送的一些有前景的研究。本综述为研究人员提供了一份快速指南，其中包含了制药领域中基于微滴的微流控技术发展方面最新科学发现的最及时且相关的信息。
