Pasz-Walczak Grazyna, Jesionek-Kupnicka Dorota, Kubiak Robert, Biernat Wojciech, Sygut Jacek, Kordek Radzisław
Department of Pathology, Medical University, Łódź.
Pol J Pathol. 2002;53(2):97-100.
Melanoma may present a great variety of cell morphology and mimic virtually almost all other neoplasms, and metastatic lesions pose major diagnostic difficulties. A typical immunoreactive profile of melanoma is: S-100p- and HMB-45-positivity, but these markers are not always present. Other new antigens for melanoma are NKIC3 and Anti-Melan-A (MART-1). This tumor may also present expression of unspecific markers, as cytokeratin, CEA, EMA, desmin, NFP, GFAP, CD68 and actins. We present here unusual features of two metastatic melanomas, showing the anaplastic pattern, immunopositive for desmin.
黑色素瘤可能呈现出多种多样的细胞形态，几乎可以模仿所有其他肿瘤，而转移性病变带来了主要的诊断困难。黑色素瘤典型的免疫反应特征是：S-100p和HMB-45呈阳性，但这些标志物并非总是存在。黑色素瘤的其他新抗原是NKIC3和抗黑色素-A（MART-1）。这种肿瘤也可能呈现非特异性标志物的表达，如细胞角蛋白、癌胚抗原、上皮膜抗原、结蛋白、神经丝蛋白、胶质纤维酸性蛋白、CD68和肌动蛋白。我们在此展示两例转移性黑色素瘤的不寻常特征，呈现间变模式，结蛋白免疫阳性。
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