横纹肌肉瘤以外的头颈部恶性肿瘤中的横纹肌母细胞分化
Rhabdomyoblastic Differentiation in Head and Neck Malignancies Other Than Rhabdomyosarcoma.
作者信息
Bishop Justin A, Thompson Lester D R, Cardesa Antonio, Barnes Leon, Lewis James S, Triantafyllou Asterios, Hellquist Henrik, Stenman Goran, Hunt Jennifer L, Williams Michelle D, Slootweg Pieter J, Devaney Kenneth O, Gnepp Douglas R, Wenig Bruce M, Rinaldo Alessandra, Ferlito Alfio
机构信息
Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins University, 401 N. Broadway, Weinberg 2249, Baltimore, MD, 21231, USA.
Southern California Permanente Medical Group, Woodland Hills, CA, USA.
出版信息
Head Neck Pathol. 2015 Dec;9(4):507-18. doi: 10.1007/s12105-015-0624-2. Epub 2015 Mar 11.
Rhabdomyosarcoma is a relatively common soft tissue sarcoma that frequently affects children and adolescents and may involve the head and neck. Rhabdomyosarcoma is defined by skeletal muscle differentiation which can be suggested by routine histology and confirmed by immunohistochemistry for the skeletal muscle-specific markers myogenin or myoD1. At the same time, it must be remembered that when it comes to head and neck malignancies, skeletal muscle differentiation is not limited to rhabdomyosarcoma. A lack of awareness of this phenomenon could lead to misdiagnosis and, subsequently, inappropriate therapeutic interventions. This review focuses on malignant neoplasms of the head and neck other than rhabdomyosarcoma that may exhibit rhabdomyoblastic differentiation, with an emphasis on strategies to resolve the diagnostic dilemmas these tumors may present. Axiomatically, no primary central nervous system tumors will be discussed.
横纹肌肉瘤是一种相对常见的软组织肉瘤，常影响儿童和青少年，且可能累及头颈部。横纹肌肉瘤通过骨骼肌分化来定义，常规组织学可提示这种分化，通过针对骨骼肌特异性标志物肌生成素或肌分化抗原1（MyoD1）的免疫组织化学可予以证实。同时，必须记住，在头颈部恶性肿瘤中，骨骼肌分化并不局限于横纹肌肉瘤。对这一现象缺乏认识可能导致误诊，进而导致不恰当的治疗干预。本综述聚焦于除横纹肌肉瘤外可能表现出横纹肌母细胞分化的头颈部恶性肿瘤，重点关注解决这些肿瘤可能带来的诊断难题的策略。当然，原发性中枢神经系统肿瘤不在讨论范围内。
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