Crespo Javier, Rivero Montserrat, Fábrega Emilio, Cayón Amalía, Amado José Antonio, García-Unzeta Maria Teresa, Pons-Romero Fernando
Gastroenterology and Hepatology Unit, University Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
Dig Dis Sci. 2002 Jul;47(7):1604-10. doi: 10.1023/a:1015835606718.
The aim of this study was to examine the possible relationship between the plasma levels of leptin and tumor necrosis factor (TNF)-alpha and the stage of hepatic fibrosis in a cohort of patients with chronic hepatitis C. Leptin and TNF levels were measured by RIA in 135 patients and in 75 age- and sex-matched controls. Liver disease was evaluated by the stage of fibrosis and the extent of inflammatory infiltrate in the liver biopsy. Leptin levels correlated with BMI values in healthy controls and in patients with chronic hepatitis C (men, r = 0.61, P = 0.0001; women, r = 0.68, P = 0.003). Leptin levels increased as hepatic fibrosis stage progressed both in male and in female patients (P < 0.001); also, TNF levels were higher in patients with an advanced stage of fibrosis (P = 0.006). In these patients, levels of leptin increased according to the progression of the stage of fibrosis; these data suggest that leptin may play a role in the regulation of hepatic fibrosis.
本研究旨在探讨慢性丙型肝炎患者队列中瘦素和肿瘤坏死因子（TNF）-α的血浆水平与肝纤维化分期之间的可能关系。采用放射免疫分析法（RIA）测定了135例患者及75例年龄和性别匹配的对照者的瘦素和TNF水平。通过肝活检中纤维化分期和炎症浸润程度评估肝脏疾病。在健康对照者和慢性丙型肝炎患者中，瘦素水平与体重指数（BMI）值相关（男性，r = 0.61，P = 0.0001；女性，r = 0.68，P = 0.003）。男性和女性患者的瘦素水平均随着肝纤维化分期的进展而升高（P < 0.001）；此外，纤维化晚期患者的TNF水平更高（P = 0.006）。在这些患者中，瘦素水平随着纤维化分期的进展而升高；这些数据表明瘦素可能在肝纤维化的调节中发挥作用。
Zotero 插件