Ghatreh-Samani Mahdi, Esmaeili Nafiseh, Soleimani Masoud, Asadi-Samani Majid, Ghatreh-Samani Keihan, Shirzad Hedayatolah
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Cent Eur J Immunol. 2016;41(1):116-24. doi: 10.5114/ceji.2015.56973. Epub 2016 Jan 20.
Iron overload in β-thalassemia major occurs mainly due to blood transfusion, an essential treatment for β-thalassemia major patients, which results in oxidative stress. It has been thought that oxidative stress causes elevation of immune system senescent cells. Under this condition, cells normally enhance in aging, which is referred to as premature immunosenescence. Because there is no animal model for immunosenescence, most knowledge on the immunosenescence pattern is based on induction of immunosenescence. In this review, we describe iron overload and oxidative stress in β-thalassemia major patients and how they make these patients a suitable human model for immunosenescence. We also consider oxidative stress in some kinds of chronic virus infections, which induce changes in the immune system similar to β-thalassemia major. In conclusion, a therapeutic approach used to improve the immune system in such chronic virus diseases, may change the immunosenescence state and make life conditions better for β-thalassemia major patients.
重型β地中海贫血中的铁过载主要是由于输血导致的，输血是重型β地中海贫血患者的一项基本治疗手段，而这会引发氧化应激。人们一直认为氧化应激会导致免疫系统衰老细胞增多。在这种情况下，细胞的衰老通常会加速，这被称为过早免疫衰老。由于不存在免疫衰老的动物模型，目前关于免疫衰老模式的大多数知识都是基于免疫衰老的诱导研究。在这篇综述中，我们描述了重型β地中海贫血患者中的铁过载和氧化应激，以及它们如何使这些患者成为免疫衰老的合适人类模型。我们还探讨了某些慢性病毒感染中的氧化应激，这些感染会引起与重型β地中海贫血类似的免疫系统变化。总之，用于改善此类慢性病毒疾病中免疫系统的治疗方法，可能会改变免疫衰老状态，改善重型β地中海贫血患者的生活状况。
