脑脊液中发热与前列腺素浓度之间的分离。
A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.
作者信息
Cranston W I, Hellon R F, Mitchell D
出版信息
J Physiol. 1975 Dec;253(2):583-92. doi: 10.1113/jphysiol.1975.sp011208.
Abstract
- Sustained fever has been induced in conscious rabbits by I.V. injection and infusion of endogenous pyrogen. 2. Cerebrospinal fluid (e.s.f.) was sampled from the cisterna magna at hourly intervals. The concentration of prostaglandin increased in parallel with rectal temperature. The prostaglandin was identified as one of the E series. 3. When sodium salicylate (1-5 m-mole followed by a continuous infusion of 9 mumole/min) was started 1 hr before endogenous pyrogen, the febrile response to the pyrogen was not significantly diminished but no rise of prostaglandin concentration was detected in c.s.f. 4. This dissociation between fever and prostaglandin concentration means that changes in cisternal prostaglandin concentration cannot be accepted as evidence that prostaglandin mediates the febrile response.
摘要
- 通过静脉注射和输注内源性致热原，在清醒兔中诱发持续发热。2. 每隔一小时从枕大池采集脑脊液（CSF）。前列腺素浓度随直肠温度平行升高。该前列腺素被鉴定为E系列之一。3. 在内源性致热原注射前1小时开始给予水杨酸钠（1 - 5毫摩尔，随后以9微摩尔/分钟持续输注），对致热原的发热反应未显著减弱，但在脑脊液中未检测到前列腺素浓度升高。4. 发热与前列腺素浓度之间的这种分离表明，不能将枕大池前列腺素浓度的变化作为前列腺素介导发热反应的证据。
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