来自华丽豆的抗菌黄酮类化合物。

Antimicrobial flavonoids from Bolusanthus speciosus.

作者信息

Bojase Gomotsang, Majinda Runner R T, Gashe Berhanu A, Wanjala Cornelius C W

机构信息

Department of Chemistry, University of Botswana, Gaborone, Botswana.

出版信息

Planta Med. 2002 Jul;68(7):615-20. doi: 10.1055/s-2002-32910.

DOI:10.1055/s-2002-32910

PMID:12142995

Abstract

A new isoflavanone namely 3,5,7,2',4'-pentahydroxy-8,3'-di(gamma,gamma-dimethylallyl)isoflavanone (bolusanthin II) and four new pterocarpans identified as 3-hydroxy-6',6'-dimethylpyrano[2',3':1,2] [6a R,11a R]-8,9-methylenedioxypterocarpan (bolucarpan A), 3-hydroxy-6',6'-dimethyl-4',5'-dihydropyrano[2',3':1,2][6a R,11a R]- 8,9-methylenedioxypterocarpan (bolucarpan B), 3-hydroxy-9-methoxy-6',6'-dimethylpyrano-[2',3':1,2][6a R,11a R]-pterocarpan (bolucarpan C) and 3-hydroxy-9-methoxy-6',6'-dimethyl-4',5'-dihydropyrano[2',3':1,2][6a R,11a R]-pterocarpan (bolucarpan D) and three known isoflavonoids were isolated from the methanolic extracts of the root bark, while eight known isoflavonoids were isolated from the stem bark of Bolusanthus speciosus. These compounds showed antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae and Candida mycoderma using the agar overlay technique.

摘要

从博卢桑图斯树根皮的甲醇提取物中分离出一种新的异黄酮，即3,5,7,2',4'-五羟基-8,3'-二（γ,γ-二甲基烯丙基）异黄酮（大叶紫檀素II）以及四种新的紫檀烷，分别鉴定为3-羟基-6',6'-二甲基吡喃并[2',3':1,2][6a R,11a R]-8,9-亚甲基二氧紫檀烷（大叶紫檀素A）、3-羟基-6',6'-二甲基-4',5'-二氢吡喃并[2',3':1,2][6a R,11a R]-8,9-亚甲基二氧紫檀烷（大叶紫檀素B）、3-羟基-9-甲氧基-6',6'-二甲基吡喃并-[2',3':1,2][6a R,11a R]-紫檀烷（大叶紫檀素C）和3-羟基-9-甲氧基-6',6'-二甲基-4',5'-二氢吡喃并[2',3':1,2][6a R,11a R]-紫檀烷（大叶紫檀素D），还分离出三种已知的异黄酮；而从大叶紫檀茎皮中分离出八种已知的异黄酮。采用琼脂覆盖技术，这些化合物对枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌、酿酒酵母和假丝酵母显示出抗菌活性。