Smith George Davey, Hart Carole
Department of Social Medicine, University of Bristol, England.
Am J Public Health. 2002 Aug;92(8):1295-8. doi: 10.2105/ajph.92.8.1295.
This study sought to demonstrate life-course influences on cardiovascular disease (CVD).
Data were derived from a prospective observational study in which the main outcome measure was death resulting from CVD.
Combining 4 socioeconomic and behavioral risk indicators into a measure of life-course exposure produced 5 groups whose relative risks of CVD mortality ranged from 1.00 (the group with the most favorable life-course exposures) to 4.55 (the group with the least favorable life-course exposures). If the entire study population had had the CVD mortality risk of the subsample with the most favorable risk factor profile, approximately two thirds of cardiovascular deaths would not have occurred.
CVD risk is influenced in a cumulative fashion by socioeconomic and behavioral factors acting throughout the life course.
本研究旨在证明生命历程对心血管疾病(CVD)的影响。
数据来自一项前瞻性观察性研究,其中主要结局指标是心血管疾病导致的死亡。
将4个社会经济和行为风险指标合并为一个生命历程暴露指标,产生了5组,其心血管疾病死亡的相对风险范围从1.00(生命历程暴露最有利的组)到4.55(生命历程暴露最不利的组)。如果整个研究人群具有风险因素特征最有利的子样本的心血管疾病死亡风险,那么大约三分之二的心血管死亡就不会发生。
心血管疾病风险受到贯穿生命历程的社会经济和行为因素的累积影响。