Salle Bernard-Louis, Delvin Edgar, Glorieux Francis
Hôpital E. Herriot, Service de néonatalogie, Place d'Arsonval, 69437 Lyon.
Bull Acad Natl Med. 2002;186(2):369-76; discussion 376-7.
During pregnancy maternal serum concentrations of 25 hydroxyvitamin D correlate with dietary vitamin D intake. Maternal serum concentrations of 1.25-dihydroxyvitamin D the hormonal circulating and active form of vitamin D are elevated, during pregnancy. 1.25-dihydoxyvitamin D is synthesized mainly by the décidual cells of the placenta and allows for increased calcium absorption. The fetus is entirely dependent on the mother for its supply of 25 (OH) D which is believed to cross easily the placenta. Vitamin D deficiency during pregnancy affects the fetus and the newborn. Birth weight is decreased, bone mineralization is impaired and neonatal hypocalcemia is frequent. In countries where dairy products are not routinely supplemented in vitamin D maternal vitamin D supplementation during pregnancy is necessary.
孕期母体血清中25-羟基维生素D的浓度与膳食维生素D摄入量相关。孕期母体血清中1,25-二羟基维生素D(维生素D的激素循环活性形式)水平会升高。1,25-二羟基维生素D主要由胎盘的蜕膜细胞合成,可增加钙的吸收。胎儿完全依赖母亲提供25(OH)D,据信其可轻易穿过胎盘。孕期维生素D缺乏会影响胎儿和新生儿。出生体重会降低,骨矿化受损,新生儿低钙血症很常见。在乳制品通常不常规添加维生素D的国家,孕期母体补充维生素D是必要的。