Woulfe John M, Hammond Robert, Richardson Bryan, Sooriabalan Danushan, Parks William, Rippstein Peter, Munoz David G
Department of Pathology and Laboratory Medicine, The University of Ottawa, The Ottawa Hospital, Ontario, Canada.
Brain Pathol. 2002 Jul;12(3):300-7. doi: 10.1111/j.1750-3639.2002.tb00444.x.
Neuronal intranuclear rodlets were described in normal brain over a century ago, but their functional significance and pathological relevance is unknown. Here, we show co-localization of tubulin and glucocorticoid receptor-like immunoreactivity in these intranuclear inclusions in human brain. In addition, we provide evidence for a massive reduction in their areal density in Alzheimer's disease brain, but not in another common neurodegenerative condition, dementia with Lewy bodies. The marked reduction of these inclusions in Alzheimer's disease may support the concept of a role for stress hormones in Alzheimer's pathogenesis.
一个多世纪前就在正常大脑中发现了神经元核内小杆,但它们的功能意义和病理相关性尚不清楚。在这里,我们展示了微管蛋白和糖皮质激素受体样免疫反应性在人脑海核内包涵体中的共定位。此外,我们提供证据表明,在阿尔茨海默病大脑中它们的面积密度大幅降低,但在另一种常见的神经退行性疾病——路易体痴呆中并非如此。这些包涵体在阿尔茨海默病中的显著减少可能支持应激激素在阿尔茨海默病发病机制中起作用这一概念。