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溶酶体与质膜：锥虫揭示了一种隐秘的关系。

Lysosomes and the plasma membrane: trypanosomes reveal a secret relationship.

作者信息

Andrews Norma W

机构信息

Section of Microbial Pathogenesis and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536, USA.

出版信息

J Cell Biol. 2002 Aug 5;158(3):389-94. doi: 10.1083/jcb.200205110. Epub 2002 Jul 29.

DOI:10.1083/jcb.200205110
PMID:12147679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2173812/
Abstract

Studies of the cell invasion mechanism of the parasite Trypanosoma cruzi led to a series of novel findings, which revealed a previously unsuspected ability of conventional lysosomes to fuse with the plasma membrane. This regulated exocytic process, previously regarded mostly as a specialization of certain cell types, was recently shown to play an important role in the mechanism by which cells reseal their plasma membrane after injury.

摘要

对寄生虫克氏锥虫细胞入侵机制的研究带来了一系列新发现，这些发现揭示了传统溶酶体与质膜融合的一种此前未被怀疑的能力。这种受调控的胞吐过程，以前大多被视为某些细胞类型的一种特殊功能，最近被证明在细胞受伤后重新封闭其质膜的机制中发挥着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ad/2173812/cf9765a68735/200205110f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ad/2173812/0279d73830a9/200205110f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ad/2173812/cf9765a68735/200205110f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ad/2173812/0279d73830a9/200205110f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79ad/2173812/cf9765a68735/200205110f2.jpg

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Pathogens. 2023 Feb 3;12(2):246. doi: 10.3390/pathogens12020246.
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