Prisant L Michael
Hypertension Unit, Section of Cardiology, Medical College of Georgia, Augusta 30912-3105, USA.
J Clin Hypertens (Greenwich). 2002 Jul-Aug;4(4):286-94. doi: 10.1111/j.1524-6175.2002.01250.x.
The lack of benefit and the potential negative side effects of beta blockers are overstated, especially in the elderly. This emphasis has led to recommendations by some investigators that these agents not be used in the management of hypertension in this age group. There are numerous reasons why these recommendations should not be followed. The use of beta blockers in the elderly hypertensive has resulted in a reduction in strokes and congestive heart failure. In addition, it should be emphasized that elderly patients are more likely to have silent coronary artery disease or sustain myocardial infarctions. There is abundant evidence that beta blockers are effective therapy in reducing mortality once a myocardial infarction has occurred. In fact, there is a clear reduction in sudden cardiac death. Furthermore, national statistics document that elderly patients have a prevalence of congestive heart failure that varies from 6%-10%. Multiple studies have now documented that beta blockers are additive to angiotensin-converting enzyme inhibitors in reducing mortality for congestive heart failure. Thus, elderly hypertensive patients may benefit from the use of beta blockers, especially if there is evidence of ischemic heart disease, cardiac arrhythmias, or congestive heart failure.
β受体阻滞剂缺乏益处以及潜在的负面副作用被夸大了,尤其是在老年人中。这种强调导致一些研究人员建议在该年龄组的高血压管理中不使用这些药物。有许多理由说明不应遵循这些建议。在老年高血压患者中使用β受体阻滞剂已导致中风和充血性心力衰竭减少。此外,应该强调的是,老年患者更有可能患有无症状冠状动脉疾病或发生心肌梗死。有充分的证据表明,一旦发生心肌梗死,β受体阻滞剂是降低死亡率的有效治疗方法。事实上,心脏性猝死明显减少。此外,国家统计数据表明,老年患者充血性心力衰竭的患病率在6%至10%之间。多项研究现已证明,在降低充血性心力衰竭死亡率方面,β受体阻滞剂与血管紧张素转换酶抑制剂具有相加作用。因此,老年高血压患者可能会从使用β受体阻滞剂中获益,特别是如果有缺血性心脏病、心律失常或充血性心力衰竭的证据。