Schroy C B, Todd P
Mutat Res. 1975 Dec;33(2-3):347-56. doi: 10.1016/0027-5107(75)90210-9.
Five cultured human cell lines (T-1 kidney, Chang liver, H.Ep. No. 2, HeLa-S3 and HeLa-O) were irradiated with ultraviolet light and immediately exposed to 1.0 and 3.0 mM caffeine for 44 h thereafter. This caffeine treatment reduced the surviving fraction (assayed by colony formation) of the irradiated population, but did not significantly reduce the colony-forming ability of unirradiated control cells. These findings suggest that many cultured human cell lines exhibit post-UV potentiation of potentially lethal damage by caffeine.
用紫外线照射五种培养的人类细胞系（T - 1肾细胞、张氏肝细胞、H.Ep. No. 2细胞、HeLa - S3细胞和HeLa - O细胞），随后立即将其暴露于1.0 mM和3.0 mM的咖啡因中44小时。这种咖啡因处理降低了受照射群体的存活分数（通过集落形成测定），但并未显著降低未受照射的对照细胞的集落形成能力。这些发现表明，许多培养的人类细胞系在紫外线照射后表现出咖啡因对潜在致死损伤的增强作用。
