Hodgkinson Rebecca, Sharples Derek
Expert Opin Investig Drugs. 2002 Aug;11(8):1023-32. doi: 10.1517/13543784.11.8.1023.
Over the past decade many well-tried chemotherapeutic agents have lost their effectiveness. This is due to a phenomenon referred to as multi-drug resistance. The most likely cause of multi-drug resistance is an increase in the activity of an efflux pump mediated through the actions of a P-glycoprotein. There is a continuing search, not only for new chemotherapeutic agents, but also for agents that can reverse the acquired resistance to existing agents.
在过去十年中，许多经过充分试验的化疗药物已失去效力。这是由于一种被称为多药耐药性的现象。多药耐药性最可能的原因是由P-糖蛋白作用介导而产生的外排泵活性增加。人们不仅在持续寻找新的化疗药物，也在寻找能够逆转对现有药物产生的获得性耐药的药物。
