Armbruster Christine
Mantlergasse 23/2/12, A-1130 Vienna, Austria.
Expert Opin Investig Drugs. 2002 Aug;11(8):1139-48. doi: 10.1517/13543784.11.8.1139.
Recurrent respiratory papillomatosis is a rare but often severe disease. Although benign in histology, epithelial proliferations may result in progressive hoarseness, stridor, obstruction of the airway and respiratory distress. The current standard of care is surgical therapy with a goal of complete removal or debulking of papillomas and preservation of normal structures. Frequent recurrences and the need for repeated surgical interventions make this treatment a frustrating experience for both the patient and the physician. Many adjuvant therapies have been investigated but no single treatment modality proved to be effective in eradicating recurrent respiratory papillomatosis. In contrast to HIV, cytomegalovirus and hepatitis B pharmaceutical research has been less successful with human papilloma virus vaccines for a variety of reasons. This review focuses on the current status of recurrent respiratory papillomatosis and on future directions of prevention and therapy.
复发性呼吸道乳头状瘤病是一种罕见但通常较为严重的疾病。尽管在组织学上为良性，但上皮增生可能导致进行性声音嘶哑、喘鸣、气道阻塞和呼吸窘迫。当前的治疗标准是手术治疗，目标是完全切除或减少乳头状瘤的体积，并保留正常结构。频繁复发以及需要反复进行手术干预，使得这种治疗对患者和医生来说都是令人沮丧的经历。已经研究了许多辅助治疗方法，但没有一种单一的治疗方式被证明能有效根除复发性呼吸道乳头状瘤病。与艾滋病毒、巨细胞病毒和乙型肝炎相比，由于各种原因，人乳头瘤病毒疫苗的药物研究不太成功。本综述重点关注复发性呼吸道乳头状瘤病的现状以及预防和治疗的未来方向。
